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Benzene image
71-43-2
Benzene
ALSO CALLED (6)Annulene, [6]Annulene, {[6]Annulene}, 1,3,5-cyclohexatriene, 1053658-43-7, 1173023-23-8, 174973-6...
Group I Human
Group II and II* Human
Ecotox
Fate
Physical
Mult
Non-GSLT
C
M
R
D
E
AT
ST
ST
N
N
SnS
SnR
IrS
IrE
AA
CA
ATB
P
B
Rx
F
PBT
GW
O
BM-1
H
H
H
M
M
L
H
H
M
H
L
L
H
H
H
H
-
vL
vL
L
H
-
-
-
-
R
All Hazards
LT-1
H
H
H
H
H-M
vH
-
H
pC
vH-M
pC
M
H
H
H
-
M
vH-H
pC
-
H
vH
-
-
-
R
PubMed Results   - - -

Hazard Lists (26 endpoints)

Endpoint Hazard Level GS Score List Name Hazard Description Other Lists
Carcinogenicity
H
LT-1
Carcinogen
H
LT-1
Carcinogen Category 1A - Known human Carcinogen based on human evidence
H
LT-1
H350 - May cause cancer
H
LT-1
Carcinogen Category 1 - Substances known to be Carcinogenic to man
H
LT-1
Group 1 - Agent is Carcinogenic to humans
H
LT-1
Carcinogen Group 1 - Substances that cause cancer in man
H
LT-1
Occupational Carcinogen
H
LT-1
(1986) Group A - Human Carcinogen
H
LT-1
(1996) Known/likely human Carcinogen
H
LT-1
Known to be a human Carcinogen
H
LT-P1
H350 - May cause cancer
H
LT-P1
Carcinogenicity - Category 1A [H350]
H
LT-P1
Carcinogenicity - Category 1 [H350 - May cause cancer]
H
LT-P1
H350 - May cause cancer
H
LT-P1
6.7A - Known or presumed human carcinogens
H
NoGS
Known human carcinogen - TSCA Criteria met
pC
NoGS
H350 - May cause cancer (unverified)
pC
NoGS
Chemicals that increased mammary gland tumors in animal studies
Mutagenicity/Genotoxicity
H
LT-1
Mutagen - Category 1B
H
LT-1
H340 - May cause genetic defects
H
LT-1
Mutagen Category 2 - Substances which should be regarded as if they are Mutagenic to man
H-M
LT-P1
Germ Cell Mutagen 3a
H
LT-P1
H340 - May cause genetic defects
H
LT-P1
Germ cell mutagenicity - Category 1 [H340 - May cause genetic defects]
H
LT-P1
H340 - May cause genetic defects
H
LT-P1
6.6A - Known or presumed human mutagens
M
LT-UNK
Germ cell mutagenicity - Category 2 [H341]
pC
NoGS
H340 - May cause genetic defects (unverified)
Reproductive Toxicity
H
LT-1
Reproductive Toxicity - Male
H
LT-P1
6.8A - Known or presumed human reproductive or developmental toxicants
M
LT-UNK
Toxic to reproduction - Category 2 [H361]
Developmental Toxicity incl. developmental neurotoxicity
H
LT-1
Developmental toxicity
Endocrine Activity
H-M
LT-P1
Potential Endocrine Disruptor
Acute Mammalian Toxicity
vH
LT-UNK
6.1B (dermal) - Acutely toxic
M
LT-UNK
Acute Toxicity (oral) - Category 4 [H302]
M
LT-UNK
6.1D (oral) - Acutely toxic
H
NoGS
H304 - May be fatal if swallowed and enters airways
H
NoGS
H304 - May be fatal if swallowed and enters airways
pC
NoGS
FIFRA Registered Pesticide
pC
NoGS
Aspiration hazard - Category 1 [H304]
pC
NoGS
Aspiration hazard - Category 1 [H304 - May be fatal if swallowed and enters airways]
Systemic Toxicity/Organ Effects incl. immunotoxicity-Repeated Exposure
H
LT-UNK
H372 - Causes damage to organs through prolonged or repeated exposure
H
LT-UNK
H372 - Causes damage to organs through prolonged or repeated exposure
pC
NoGS
H372 - Causes damage to organs through prolonged or repeated exposure (unverified)
Neurotoxicity-Single Exposure
pC
NoGS
H336 - May cause drowsiness or dizziness (unverified)
Neurotoxicity-Repeated Exposure
vH-M
LT-UNK
Neurotoxic
Skin Sensitization
pC
NoGS
Potential Skin Allergens
Respiratory Sensitization
M
NoGS
Asthma - irritant - limited evidence
Skin Irritation/Corrosivity
H
LT-UNK
H315 - Causes skin irritation
H
LT-UNK
Skin corrosion / irritation - Category 2 [H315]
H
LT-UNK
H315 - Causes skin irritation
H
LT-UNK
Skin corrosion/irritation - Category 2 [H315 - Causes skin irritation]
H
LT-UNK
H315 - Causes skin irritation
H
LT-UNK
6.3A - Irritating to the skin (Cat. 2)
pC
NoGS
H315 - Causes skin irritation (unverified)
Eye Irritation/Corrosivity
H
LT-UNK
H319 - Causes serious eye irritation
H
LT-UNK
Serious eye damage / eye irritation - Category 2A [H319]
H
LT-UNK
Serious eye damage/irritation - Category 2 [H319 - Causes serious eye irritation]
H
LT-UNK
H319 - Causes serious eye irritation
H
LT-UNK
H319 - Causes serious eye irritation
H
LT-UNK
6.4A - Irritating to the eye (Cat. 2A)
pC
NoGS
H319 - Causes serious eye irritation (unverified)
Acute Aquatic Toxicity
H
LT-UNK
Hazardous to the aquatic environment (acute) - Category 2 [H401]
Terrestrial Ecotoxicity
M
NoGS
9.3C - Harmful to terrestrial vertebrates
Persistence
vH-H
LT-UNK
Persistent
pC
NoGS
Low environmental persistence - TSCA Criteria met
Bioaccumulation
pC
NoGS
Low bioaccumulation potential - TSCA Criteria met
Flammability
H
LT-UNK
H225 - Highly flammable liquid and vapour
H
LT-UNK
H225 - Highly flammable liquid and vapour
H
LT-UNK
Flammable liquids - Category 2 [H225]
H
LT-UNK
Flammable liquids - Category 2 [H225 - Highly flammable liquid and vapour]
H
LT-UNK
H225 - Highly flammable liquid and vapour
H
LT-UNK
3.1B - Flammable Liquids: high hazard
vH-M
LT-UNK
Class B2 - Flammable liquids
pC
NoGS
H225 - Highly flammable liquid and vapour (unverified)
Carcinogenicity, Mutagenicity/Genotoxicity Reproductive Toxicity and/or Developmental Toxicity
U
LT-P1
CMR - Carcinogen, Mutagen &/or Reproductive Toxicant
Human and/or Aquatic toxicity and/or Persistence and/or Bioaccumulation
U
LT-UNK
CEPA Toxics
U
LT-P1
Class 3 - Severe Hazard to Waters
T & P and/or B [(Chronic Aquatic Toxicity and sometimes Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
LT-P1
Hazardous to the aquatic environment (chronic) - Category 2 [H411]
U
LT-P1
Hazardous to the aquatic environment (chronic) - Category 2 [H411 - Toxic to aquatic life with long lasting effects]
Systemic Toxicity/Organ Effects [Repeated Exposure] and/or Neurotoxicity [Repeated Exposure]
H
LT-UNK
Specific target organs/systemic toxicity following repeated exposure - Category 1 [H372]
H
LT-UNK
Specific target organ toxicity - Repeated exposure - Category 1 [H372 - Causes damage to organs through prolonged or repeated exposure]
H
LT-UNK
H372 - Causes damage to organs through prolonged or repeated exposure
Systemic Toxicity/Organ Effects [Single Exposure] and/or Neurotoxicity [Single Exposure]
vH
LT-UNK
Specific target organs/systemic toxicity following single exposure - Category 1 [H370]
vH
LT-UNK
6.9A (inhalation) - Toxic to human target organs or systems (Cat. 1)
vH
LT-UNK
6.9A (oral) - Toxic to human target organs or systems (Cat. 1)
T & P and/or B [(Chronic Aquatic Toxicity and Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
LT-UNK
9.1D (algal) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
U
LT-UNK
9.1D (crustacean) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
U
LT-UNK
9.1D (fish) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
pC
NoGS
H412 - Harmful to aquatic life with long lasting effects (unverified)
Systemic Toxicity/Organ Effects (Single Exposure - Aspiration Hazard)
H
LT-UNK
H304 - May be fatal if swallowed and enters airways
pC
NoGS
H304 - May be fatal if swallowed and enters airways (unverified)
Carcinogenicity,Mutagenicity/Genotoxicity Reproductive Toxicity, Developmental Toxicity, Acute Mammalian Toxicity, or System Toxicity/Organ Effects.
U
LT-UNK
Class D2A - Very toxic material causing other toxic effects
U
LT-UNK
Class D2B - Toxic material causing other toxic effects
Endpoint Hazard Level Hazard List Hazard Description Other Lists
Cancer
High
Carcinogen
High Carcinogen Category 1A - Known human Carcinogen based on human evidence
High H350 - May cause cancer
High Carcinogen Category 1 - Substances known to be Carcinogenic to man
High Group 1 - Agent is Carcinogenic to humans
High Carcinogen Group 1 - Substances that cause cancer in man
High Occupational Carcinogen
High (1986) Group A - Human Carcinogen
High (1996) Known/likely human Carcinogen
High Known to be a human Carcinogen
High H350 - May cause cancer
High Carcinogenicity - Category 1A [H350]
High Carcinogenicity - Category 1 [H350 - May cause cancer]
High H350 - May cause cancer
High 6.7A - Known or presumed human carcinogens
High Known human carcinogen - TSCA Criteria met
Potential Concern H350 - May cause cancer (unverified)
Potential Concern Chemicals that increased mammary gland tumors in animal studies
Developmental
High
Developmental toxicity
Reproductive
High
Reproductive Toxicity - Male
High 6.8A - Known or presumed human reproductive or developmental toxicants
Medium Toxic to reproduction - Category 2 [H361]
Gene mutation
High
Mutagen - Category 1B
High H340 - May cause genetic defects
High Mutagen Category 2 - Substances which should be regarded as if they are Mutagenic to man
Medium Germ Cell Mutagen 3a
High H340 - May cause genetic defects
High Germ cell mutagenicity - Category 1 [H340 - May cause genetic defects]
High H340 - May cause genetic defects
High 6.6A - Known or presumed human mutagens
Medium Germ cell mutagenicity - Category 2 [H341]
Potential Concern H340 - May cause genetic defects (unverified)
Persistent
High
Persistent
Potential Concern Low environmental persistence - TSCA Criteria met
Endocrine
Medium
Potential Endocrine Disruptor
Mammalian
High
H304 - May be fatal if swallowed and enters airways
Very High 6.1B (dermal) - Acutely toxic
Medium Acute Toxicity (oral) - Category 4 [H302]
Medium 6.1D (oral) - Acutely toxic
High H304 - May be fatal if swallowed and enters airways
High H304 - May be fatal if swallowed and enters airways
Potential Concern FIFRA Registered Pesticide
Potential Concern H304 - May be fatal if swallowed and enters airways (unverified)
Potential Concern Aspiration hazard - Category 1 [H304]
Potential Concern Aspiration hazard - Category 1 [H304 - May be fatal if swallowed and enters airways]
Organ toxicant
High
H372 - Causes damage to organs through prolonged or repeated exposure
Very High Specific target organs/systemic toxicity following single exposure - Category 1 [H370]
Very High 6.9A (inhalation) - Toxic to human target organs or systems (Cat. 1)
Very High 6.9A (oral) - Toxic to human target organs or systems (Cat. 1)
High H372 - Causes damage to organs through prolonged or repeated exposure
High Specific target organs/systemic toxicity following repeated exposure - Category 1 [H372]
High Specific target organ toxicity - Repeated exposure - Category 1 [H372 - Causes damage to organs through prolonged or repeated exposure]
High H372 - Causes damage to organs through prolonged or repeated exposure
Potential Concern H372 - Causes damage to organs through prolonged or repeated exposure (unverified)
Acute aquatic
High
Hazardous to the aquatic environment (acute) - Category 2 [H401]
Medium 9.1D (algal) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
Medium 9.1D (crustacean) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
Medium 9.1D (fish) - Slightly harmful in the aquatic environment or are otherwise designed for biocidal action
Chron aquatic
High
Hazardous to the aquatic environment (chronic) - Category 2 [H411]
Medium Hazardous to the aquatic environment (chronic) - Category 2 [H411 - Toxic to aquatic life with long lasting effects]
Potential Concern H412 - Harmful to aquatic life with long lasting effects (unverified)
Flammable
High
H225 - Highly flammable liquid and vapour
High H225 - Highly flammable liquid and vapour
High Flammable liquids - Category 2 [H225]
High Flammable liquids - Category 2 [H225 - Highly flammable liquid and vapour]
High H225 - Highly flammable liquid and vapour
High 3.1B - Flammable Liquids: high hazard
Potential Concern Class B2 - Flammable liquids
Potential Concern H225 - Highly flammable liquid and vapour (unverified)
Respiratory
Medium
Asthma - irritant - limited evidence
Eye irritation
High
H319 - Causes serious eye irritation
High Serious eye damage / eye irritation - Category 2A [H319]
High Serious eye damage/irritation - Category 2 [H319 - Causes serious eye irritation]
High H319 - Causes serious eye irritation
High H319 - Causes serious eye irritation
High 6.4A - Irritating to the eye (Cat. 2A)
Potential Concern H319 - Causes serious eye irritation (unverified)
Skin irritation
High
H315 - Causes skin irritation
High Skin corrosion / irritation - Category 2 [H315]
High H315 - Causes skin irritation
High Skin corrosion/irritation - Category 2 [H315 - Causes skin irritation]
High H315 - Causes skin irritation
High 6.3A - Irritating to the skin (Cat. 2)
Potential Concern H315 - Causes skin irritation (unverified)
Terrestrial
Medium
9.3C - Harmful to terrestrial vertebrates
Multiple
Medium
Class D2A - Very toxic material causing other toxic effects
Medium Class D2B - Toxic material causing other toxic effects
Potential Concern CMR - Carcinogen, Mutagen &/or Reproductive Toxicant
Potential Concern CEPA Toxics
Potential Concern Class 3 - Severe Hazard to Waters
Skin sensitize
Potential Concern
Potential Skin Allergens
Restricted list
Potential Concern
2019 Substance of Concern List
Potential Concern V3 2014 Substance of Concern List
Potential Concern Candidate Chemical List
Potential Concern Chemicals of Concern
Potential Concern Priority Chemicals
Potential Concern Limit of harmful substances in industrial protective coatings (GB 30981-2020)
Potential Concern Limit standard for volatile organic compounds content in adhesives (GB 33372-2020)
Potential Concern Limit standard for volatile organic compounds content in cleaning agents (GB 38508-2020)
Potential Concern Limit standard for volatile organic compounds content in printing inks (GB 38507-2020)
Potential Concern CoHC List (non SVHC)
Potential Concern Children's Products
Potential Concern Core Restrictions
Potential Concern Cosmetics & Personal Care Products
Potential Concern Formulated Consumer Products
Potential Concern Prohibited Chemicals
Potential Concern Annex II - Prohibited Substances
Potential Concern Substances selected for RMOA or hazard assessment
Potential Concern Substances restricted under REACH
Potential Concern Restrictions for Manufacturing Process
Potential Concern Ingredients that are Prohibited for Use in Cosmetic Products
Potential Concern Prohibition
Potential Concern Specification
Potential Concern Reportable Chemicals
Potential Concern Chemicals of High Concern
Potential Concern Chemicals of High Concern
Potential Concern Chemicals of high concern
Potential Concern HAPs subject to the Clean Air Act
Potential Concern Cancer causing substances subject to workplace management or avoidance
Potential Concern Chemicals of High Concern to Children
Potential Concern Chemicals of High Concern to Children
Potential Concern ZDHC - MRSL v1.1 for Natural Leather Processing
Potential Concern ZDHC - MRSL v1.1 for Textiles and Synthetic Leather Processing
Neurotoxicity
Potential Concern
Neurotoxic
Potential Concern H336 - May cause drowsiness or dizziness (unverified)
Bioaccumulative
Potential Concern
Low bioaccumulation potential - TSCA Criteria met

Cradle to Cradle Certified™ List Hazards

Acute and Chronic Tox. Acute Aquatic Tox. Chronic Aquatic Tox.
C
M
R+D
E
O
D
I
O/D/I
N
IrS+IrE
SnS+SnR
Fish
Inv.
Alg.
Any
Fish
Inv.
Alg.
Any
T
P
B
Climate
Organohalogen
Toxic Metal
Other
Mult
R
R
R
R/Y
R
?
?
R
R/Y
Y
?
-
-
-
R
?
?
?
R
?
R/Y
?
G
NL
NL
R
R

Full Hazard List By Endpoint

Endpoint Lists
Carcinogenicity
Mutagenicity
Reproductive Toxicity (Repro + Dev)
Endocrine Disruption
Oral Toxicity
Dermal Toxicity
Inhalative Toxicity
Oral, Dermal, and/or Inhalative Toxicity
Neurotoxicity
Skin, Eye, and Respiratory Corrosion/Irritation
Skin and Respiratory Sensitization
Acute Aquatic Toxicity (Fish) not listed
Acute Aquatic Toxicity (Invertibrates) not listed
Acute Aquatic Toxicity (Algae) not listed
Acute Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
Chronic Aquatic Toxicity (Fish)
Chronic Aquatic Toxicity (Invertibrates)
Chronic Aquatic Toxicity (Algae)
Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
Terrestrial
Persistence
Bioaccumulation
Climatic Relevance not listed
Organohalogen not listed - This chemical is not on the Pharos list of organohalogens, but we may have missed a few. Please double-check the chemical structure to confirm there are no carbon-halogen bonds.
Toxic Metal not listed - This chemical is not on the Pharos list of toxic metals, but we may have missed a few. Please double-check the chemical structure to confirm there are no toxic metals.
Other (Human Health)
Multiple Endpoints

Restricted Substance Lists (32)

Discussions

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