EU - GHS (H-Statements)

Regulation on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) Annex 6 Table 3-1 - GHS Hazard code criteria
Annex VI Table 3-1 lists chemicals and their required warnings.  They can be found in the ...

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Annex VI Table 3-1 lists chemicals and their required warnings.  They can be found in the Classification & Labelling (C&L) Inventory database.

 

Background

In order to harmonize previously inconsistent label warnings and Safety Data Sheets for the same chemical, the European Parliament and Council adopted the Regulation on the Classification, Labelling and Packaging of Substances and Mixtures (CLP), Regulation 1272/2008. It entered into force on 20 January 2009. The Regulation incorporates the classification criteria and labelling rules agreed at UN level, the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). It introduces new classification criteria, hazard symbols (pictograms) and labelling phrases, while taking account of elements which are part of the earlier EU legislation.

Originally published in ECB, Annex I of Directive 67-548-EEC and subsequent amendments/adaptations, known as the Dangerous Substances Directive (DSD) or Directive on Dangerous Substances (DDS).

 

The M-factor is a multiplying factor. The concept of M-factors has been established to give an increased weight to substances that are very toxic for the aquatic environment when classifying mixtures containing these substances.

More information on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) can be found at: http://ec.europa.eu/environment/chemicals/ghs/index_en.htm

http://ec.europa.eu/enterprise/sectors/chemicals/classification/index_en.htm

Explanation of the CLP regulation: http://echa.europa.eu/regulations/clp and http://ec.europa.eu/enterprise/sectors/chemicals/documents/classification/

 

About the GHS: http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html

   http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html

Regulation (EC) No 1272/2008 on the CLP: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:32008R1272:EN:NOT

GHS Annex 3 which includes listing of all hazard codes  http://www.unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev02/English/07e_annex3.pdf

EXCLUSIONS: Currently Pharos only accomodates substances that have a CAS number, plus select compound groups. The CLP includes a significant number of substances which do not have a CAS number and are not listed in Pharos at this time. The CLP also includes a number of compund groups which Pharos has not yet characterized.

Agency
European Union / European Commission (EU EC)
Updated
2019-03-26
Website
http://echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-...
Hazards for Hazard List
Endpoint Hazard Rating and Description GS Score HPD C2C
Reactivity
vH
H200 - Unstable explosive [Explosives - Unstable explosive] LT-UNK Priority List Other (Human Health) (Red)
Flammability
vH
H224 - Extremely flammable liquid and vapour [Flammable liquids - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
vH
H240 - Heating may cause an explosion [Self-reactive substances and mixtures; and Organic peroxides - Type or A] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
vH
H241 - Heating may cause a fire or explosion [Self-reactive substances and mixtures; and Organic peroxides - Type or B] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
vH
H260 - In contact with water releases flammable gases which may ignite spontaneously [Substances and mixtures which, in contact with water, emit flammable gases - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
vH
H271 - May cause fire or explosion; strong oxidiser [Oxidizing liquids; Oxidizing solids - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Acute Mammalian Toxicity
vH
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1 or 2] LT-UNK Priority List Oral Toxicity (Red)
Acute Mammalian Toxicity
vH
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1 or 2] LT-UNK Priority List Dermal Toxicity (Red)
Skin Irritation/Corrosivity
vH
H314 - Causes severe skin burns and eye damage [Skin corrosion/irritation - Category 1A or 1B or 1C] LT-UNK Priority List Skin, Eye, and Respiratory Corrosion/Irritation (Red)
Eye Irritation/Corrosivity
vH
H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1] LT-UNK Priority List Skin, Eye, and Respiratory Corrosion/Irritation (Red)
Acute Mammalian Toxicity
vH
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2] LT-UNK Priority List Inhalative Toxicity (Red)
Systemic Toxicity/Organ Effects-Single Exposure
vH
H370 - Causes damage to organs [Specific target organ toxicity - single exposure - Category 1] LT-UNK Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
Acute Aquatic Toxicity
vH
H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1] LT-UNK Priority List Acute Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
Mutagenicity/Genotoxicity
H
H340 - May cause genetic defects [Germ cell mutagenicity - Category 1A or 1B] LT-1 Priority List Mutagenicity (Red)
Carcinogenicity
H
H350 - May cause cancer [Carcinogenicity - Category 1A or 1B] LT-1 Priority List Carcinogenicity (Red)
Carcinogenicity
H
H350i - May cause cancer by inhalation [Carcinogenicity - Category 1A or 1B] LT-1 Priority List Carcinogenicity (Red)
Developmental Toxicity incl. developmental neurotoxicity
H
H360D - May damage the unborn child [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Reproductive Toxicity
H
H360F - May damage fertility [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Reproductive and/or Developmental Toxicity
H
H360FD - May damage fertility. May damage the unborn child [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Multiple Endpoints (Red)
Developmental Toxicity incl. developmental neurotoxicity
H
H362 - May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Reactivity
H
H201 - Explosive; mass explosion hazard [Explosives - Division 1.1] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
H
H202 - Explosive, severe projection hazard [Explosives - Division 1.2] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
H
H203 - Explosive; fire, blast or projection hazard [Explosives - Division 1.3] LT-UNK Priority List Other (Human Health) (Red)
Flammability
H
H220 - Extremely flammable gas [Flammable gases - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Flammability
H
H222 - Extremely flammable aerosol [Flammable aerosols - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Flammability
H
H225 - Highly flammable liquid and vapour [Flammable liquids - Category 2] LT-UNK Priority List Other (Human Health) (Red)
Flammability
H
H250 - Catches fire spontaneously if exposed to air [Pyrophoric liquids; Pyrophoric solids - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
H
H251 - Self-heating: may catch fire [Self-heating; substances and mixtures - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Reactivity
H
H270 - May cause or intensify fire; oxidiser (GAS ONLY) [Oxidizing gases - Category 1] LT-UNK Priority List Other (Human Health) (Red)
Systemic Toxicity/Organ Effects (Single Exposure - Aspiration Hazard)
H
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] LT-UNK Priority List Oral Toxicity (Red)
Acute Mammalian Toxicity
H
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3] LT-UNK Priority List Dermal Toxicity (Red)
Systemic Toxicity/Organ Effects incl. immunotoxicity-Repeated Exposure
H
H372 - Causes damage to organs through prolonged or repeated exposure [Specific target organ toxicity - repeated exposure - Category 1] LT-UNK Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
Acute Mammalian Toxicity
H
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3] LT-UNK Priority List Oral Toxicity (Red)
Skin Irritation/Corrosivity
H
H315 - Causes skin irritation [Skin corrosion/irritation - Category 2] LT-UNK Priority List Skin, Eye, and Respiratory Corrosion/Irritation (Yellow)
Eye Irritation/Corrosivity
H
H319 - Causes serious eye irritation [Serious eye damage/eye irritation - Category 2A] LT-UNK Priority List Skin, Eye, and Respiratory Corrosion/Irritation (Yellow)
Acute Mammalian Toxicity
H
H331 - Toxic if inhaled [Acute toxicity (inhalation) - Category 3] LT-UNK Priority List Inhalative Toxicity (Red)
Systemic Toxicity/Organ Effects-Single Exposure
H
H371 - May cause damage to organs [Specific target organ toxicity - single exposure - Category 2] LT-UNK Priority List Oral, Dermal, and/or Inhalative Toxicity (Yellow)
Developmental Toxicity incl. developmental neurotoxicity
H-M
H360Df - May damage the unborn child. Suspected of damaging fertility [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Developmental Toxicity incl. developmental neurotoxicity
H-M
H360Fd - May damage fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Mutagenicity/Genotoxicity
M
H341 - Suspected of causing genetic defects [Germ cell mutagenicity - Category 2] LT-UNK Priority List Mutagenicity (Red)
Carcinogenicity
M
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] LT-UNK Priority List Carcinogenicity (Red)
Reproductive and/or Developmental Toxicity
M
H361 - Suspected of damaging fertility or the unborn child [Reproductive toxicity - Category 2] LT-UNK Priority List Multiple Endpoints (Red)
Developmental Toxicity incl. developmental neurotoxicity
M
H361d - Suspected of damaging the unborn child [Reproductive toxicity - Category 2] LT-UNK Priority List Reproductive Toxicity (Repro + Dev) (Red)
Reproductive Toxicity
M
H361f - Suspected of damaging fertility [Reproductive toxicity - Category 2] LT-UNK Priority List Reproductive Toxicity (Repro + Dev) (Red)
Reproductive and/or Developmental Toxicity
M
H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 2] LT-UNK Priority List Multiple Endpoints (Red)
Reactivity
M
H204 - Fire or projection hazard [Explosives - Division 1.4] LT-UNK Other (Human Health) (Yellow)
Reactivity
M
H205 - May mass explode in fire [Explosives - Division 1.5] LT-UNK Other (Human Health) (Yellow)
Flammability
M
H221 - Flammable gas [Flammable gases - Category 2] LT-UNK Other (Human Health) (Yellow)
Flammability
M
H223 - Flammable aerosol [Flammable aerosols - Category 2] LT-UNK Other (Human Health) (Yellow)
Flammability
M
H226 - Flammable liquid and vapour [Flammable liquids - Category 3] LT-UNK Other (Human Health) (Yellow)
Flammability
M
H227 - Combustible liquid [Flammable liquids - Category 4] LT-UNK Other (Human Health) (Yellow)
Flammability
M
H230 - May react explosively even in the absence of air [Flammable solids - Category 1A, Chemically unstable gas A] LT-UNK Other (Human Health) (Yellow)
Reactivity
M
H252 - Self-heating in large quantities; may catch fire [Self-heating; substances and mixtures - Category 2] LT-UNK Other (Human Health) (Yellow)
Reactivity
M
H290 - May be corrosive to metals [Corrosive to metals - Category 1] LT-UNK Other (Human Health) (Yellow)
Acute Mammalian Toxicity
M
H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4] LT-UNK Oral Toxicity (Red or Yellow)
Acute Mammalian Toxicity
M
H312 - Harmful in contact with skin [Acute toxicity (dermal) - Category 4] LT-UNK Dermal Toxicity (Red or Yellow)
Eye Irritation/Corrosivity
M
H320 - Causes eye irritation [Serious eye damage/eye irritation - Category 2B] LT-UNK Skin, Eye, and Respiratory Corrosion/Irritation (Yellow)
Acute Mammalian Toxicity
M
H332 - Harmful if inhaled [Acute toxicity (inhalation) - Category 4] LT-UNK Inhalative Toxicity (Red or Yellow)
Systemic Toxicity/Organ Effects-Single Exposure
M
H335 - May cause respiratory irritation [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3] LT-UNK Inhalative Toxicity (Yellow)
Systemic Toxicity/Organ Effects incl. immunotoxicity-Repeated Exposure
M
H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organ toxicity - repeated exposure - Category 2] LT-UNK Oral, Dermal, and/or Inhalative Toxicity (Yellow)
Reproductive and/or Developmental Toxicity
H
H360 - May damage fertility or the unborn child [Reproductive toxicity - Category 1A or 1B] LT-1 Priority List Reproductive Toxicity (Repro + Dev) (Red)
Flammability
H-M
H228 - Flammable solid [Flammable solids - Category 1 or 2] LT-UNK Priority List Other (Human Health) (Red or Yellow)
Reactivity
H-M
H261 - In contact with water releases flammable gases [Substances and mixtures which, in contact with water, emit flammable gases - Category 2 or 3] LT-UNK Priority List Other (Human Health) (Red or Yellow)
Reactivity
H-M
H272 - May intensify fire; oxidiser [Oxidizing liquids; Oxidizing solids - Category 2 or 3] LT-UNK Priority List Other (Human Health) (Red or Yellow)
Skin Sensitization
H-M
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1] LT-UNK Priority List Skin and Respiratory Sensitization (Red)
Respiratory Sensitization
H-M
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled [Respiratory sensitization - Category 1] LT-UNK Priority List Skin and Respiratory Sensitization (Red)
Neurotoxicity-Single Exposure
M-L
H336 - May cause drowsiness or dizziness [Specific target organ toxicity - single exposure; Narcotic effects - Category 3] LT-UNK Inhalative Toxicity (Yellow)
Ozone Depletion
H
H420 - Hazardous to the Ozone Layer (formerly EUH059) [Hazardous to the ozone layer - Category 1] NoGS Priority List
Acute Aquatic Toxicity
H
H401 - Aquatic Acute 2 - Toxic to aquatic life (DELETED EU does not use Cat 2) [Hazardous to the aquatic environment (acute) - Category 2] NoGS Priority List Acute Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
Skin Irritation/Corrosivity
M
H316 - Causes mild skin irritation [Skin corrosion/irritation - Category 3] NoGS Skin, Eye, and Respiratory Corrosion/Irritation
Acute Aquatic Toxicity
M
H402 - Aquatic Acute 3 - Harmful to aquatic life (DELETED Ue does not use CAT 3) [Hazardous to the aquatic environment (acute) - Category 3] NoGS Acute Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
Acute Mammalian Toxicity
L
H313 - May be harmful in contact with skin [Acute toxicity (dermal) - Category 5] NoGS Dermal Toxicity
Acute Mammalian Toxicity
L
H333 - May be harmful if inhaled [Acute toxicity (inhalation) - Category 5] NoGS Inhalative Toxicity
T & P and/or B [(Chronic Aquatic Toxicity and Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
H413 - May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment (chronic) - Category 4] LT-UNK Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
Reactivity
vH-M
H242 - Heating may cause a fire [Self-reactive substances and mixtures; and Organic peroxides - Types C or D or E or F] LT-UNK Priority List Other (Human Health) (Red or Yellow)
T & P and/or B [(Chronic Aquatic Toxicity and Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] LT-P1 Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
T & P and/or B [(Chronic Aquatic Toxicity and Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] LT-P1 Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
T & P and/or B [(Chronic Aquatic Toxicity and Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)]
U
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] LT-UNK Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)

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